Just out of curiosity, if you were opening a restaurant in a building known for a recent wave of temporary businesses, would you dare name it Up A Creek?
Me? Not so much. According to the Urban Dictionary, "up a creek" an adjective "is the same as up shit creek, which means to be in trouble with no solution." For example, I was up a creek when the bill collector came.
I hope the owner's didn't jinx themselves when they named their restaurant. Best of luck to Up a Creek, may there be nothing behind the name and your business will last longer than the ones that came before you.